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Invitrogen
pro-MMP7 Monoclonal Antibody (377313)
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产品信息
MA5-61236
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
377313
抗原
Mouse myeloma cell line NS0-derived recombinant mouse MMP-7, Leu18-Leu264
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Pro-MMP7 (pro-Matrix Metallopeptidase 7) is a gene that encodes the inactive precursor of MMP7, an enzyme belonging to the matrix metalloproteinase (MMP) family. MMP7, also known as matrilysin, is involved in the breakdown of extracellular matrix components, which is crucial for various physiological processes such as tissue remodeling, wound healing, and embryonic development. Unlike other MMPs, MMP7 has a broad substrate specificity and can degrade a variety of extracellular matrix proteins, including casein, gelatins, fibronectin, and proteoglycans. The activation of pro-MMP7 to its active form is tightly regulated, often requiring proteolytic cleavage. Dysregulation of MMP7 activity has been implicated in pathological conditions such as cancer, where it can promote tumor invasion and metastasis, as well as in inflammatory diseases. Understanding the regulation and function of pro-MMP7 is essential for developing therapeutic strategies aimed at modulating its activity in various diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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