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Invitrogen
pro-Renin Monoclonal Antibody (434717)
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产品信息
MA5-61411
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
434717
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Renin 1, Leu22-Arg402
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Pro-renin is the precursor form of renin, an enzyme that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure, fluid and electrolyte balance, and systemic vascular resistance. Pro-renin is synthesized and secreted by the juxtaglomerular cells of the kidney. Once in the bloodstream, it can be activated to renin, which then cleaves angiotensinogen to produce angiotensin I. Angiotensin I is subsequently converted to angiotensin II, a potent vasoconstrictor, by the angiotensin-converting enzyme (ACE). Angiotensin II has multiple effects, including increasing blood pressure, stimulating aldosterone secretion from the adrenal glands, and promoting sodium and water reabsorption by the kidneys. Elevated levels of pro-renin and renin are associated with hypertension, heart failure, and chronic kidney disease. Understanding the regulation and function of pro-renin is essential for developing therapeutic strategies aimed at modulating the RAAS pathway to treat cardiovascular and renal diseases. Pro-renin and its receptor also represent potential targets for novel drug development in the management of these conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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