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NeoBiotechnologies
von Willebrand Factor/Factor VIII Related-Ag (Endothelial Marker) Recombinant Rabbit Monoclonal Antibody (MSVA-521R)
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von Willebrand Factor/Factor VIII Related-Ag (Endothelial Marker) Antibody (7450-RBM29-P1) in IHC (P)
von Willebrand factor Rabbit Recombinant Monoclonal Antibody (MSVA-521R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
产品信息
7450-RBM29-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MSVA-521R
抗原
Recombinant fragment of human vWF protein (aa 1815-1939) (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cell membrane, Cytoplasm, Cytoskeleton, Nucleus matrix.
Positive control: Liver: Kupffer cells must show a strong staining and sinusoidal endothelial cells should show an at least a weak staining. Colon: Endothelial and muscle cells of large vessels and stromal cells must show a strong Vimentin staining while dispersed intraepithelial T-cells must show an at least moderate intensity staining.
Tissue specificity: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
靶标信息
Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coagulation Factor VIII; coagulation factor VIII VWF; factor viii related antigen; von Willebrand Disease (vWD); von Willebrand factor; vWF
基因别名: F8VWF; VWD; VWF
UniProt ID: (Human) P04275
Entrez Gene ID: (Human) 7450
