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Invitrogen
vpx Polyclonal Antibody
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vpx Antibody (PA5-144354) in WB
Western blot analysis of vpx in recombinant protein using a dilution of 2.6 µg/mL. Samples were incubated with vpx polyclonal antibody (Product # PA5-144354). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.
产品信息
PA5-144354
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)
偶联物
形式
Liquid
浓度
3.92 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% Proclin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Viral protein X; vpxProtein Vpx; X ORF protein
