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Invitrogen
4E-BP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17527
产品规格
种属反应
Bovine,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues at the carboxy-terminus of human 4E-BP2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
20 µg/mL
规格
2 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4E-BP2; eIF4E-binding protein 2; Eukaryotic translation initiation factor 4E-binding protein 2; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2
基因别名: 2810011I19Rik; 4E-BP2; AA792569; BC010348; EIF4EBP2; PHAS-II
UniProt ID: (Mouse) P70445
Entrez Gene ID: (Bovine) 782397, (Rat) 361845, (Mouse) 13688
translational initiation
insulin receptor signaling pathway
cAMP-mediated signaling
negative regulation of translational initiation
regulation of translation
regulation of translational initiation
memory
negative regulation of translation
TOR signaling
social behavior
regulation of synaptic plasticity
modulation of synaptic transmission
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