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Invitrogen
5-Carboxylcytosine Recombinant Rabbit Monoclonal Antibody (RM462)
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5-Carboxylcytosine Antibody (MA5-44548) in ELISA
ELISA analysis of DNA using 5-Carboxylcytosine Recombinant Monoclonal antibody (Product # MA5-44548) at a dilution of 1 µg/mL. The plate was coated with different concentrations of linear ssDNA (426 bp) containing either normal cytosines (unmodified), 5-methylcytosines (5-mC), 5-hydroxymethylcytosines (5-hmC), 5-carboxylcytosines (5-caC), or 5-formylcytosines (5-fC).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-44548
产品规格
种属反应
Chemical
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM462
抗原
KLH-conjugated 5-Carboxylcytosine.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts to human NeuN (Fox3, RBFOX3). The clone may also react to mouse or rat NeuN, as predicted by immunogen homology.
靶标信息
5-carboxylcytosine is the final oxidized derivative of 5-methylcytosine, a type of DNA methylation. 5-methylcytosine is oxidized to 5-hydroxymethylcytosine which is then oxidized to 5-formylcytosine and later to 5-carboxylcytosine. These oxidations are catalyzed by the Ten-Eleven Translocation (TET) enzyme family. 5-carboxylcytosine has been shown to cause reduced fidelity of RNA Polymerase II. Decreased levels of 5-hydroxymethylcytosine has been found in some cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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