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Invitrogen
53BP1 Polyclonal Antibody, HRP
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产品信息
PA5-22793
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a portion of human 53BP1 encoded in exon 11, 12 and 19.
偶联物
HRP
HRP
HRP
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts with Human samples in Western blot and ICC applications, and with Mouse in ICC applications.
Predicted cross-reactivity based on sequence identity: Chimpanzee/Orangutan (99%), Gibbon/Gorilla (98%), Marmoset (95%).
靶标信息
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 53BP1; FLJ41424; MGC138366; murine p53-binding protein; p53-binding protein 1; TP53-binding protein 1; transformation related protein 53 binding-protein 1; tumor suppressor p53-binding protein 1
基因别名: 53BP1; m53BP1; p53BP1; Tp53bp1; Trp53bp1
UniProt ID: (Mouse) P70399
Entrez Gene ID: (Mouse) 27223
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