Invitrogen

AASS Polyclonal Antibody

Name: AASS Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-54250
Price: 4554.00 CNY
Availability: InStock

高级验证

查看其他6个AASS抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (8)
高级验证 (1)

AASS Antibody in Immunocytochemistry (ICC/IF)

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AASS Antibody (PA5-54250) in ICC/IF

Immunofluorecent analysis of AASS in human cell line U-2 OS using AASS Polyclonal Antibody (Product # PA5-54250). Staining shows localization to mitochondria and vesicles.

AASS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

AASS Antibody in Immunohistochemistry (IHC)

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

AASS Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of AASS demonstrates antibody specificity. Immunohistochemical analysis of AASS using anti-AASS Polyclonal Antibody (Product # PA5-54250), shows significant staining of AASS in human liver and shows minimal or weak staining in human skeletal muscle tissues. The relative expression levels of AASS within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image AASS Polyclonal Antibody

产品信息

PA5-54250

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human AASS. Recombinant protein control fragment (Product #RP-92605).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

10 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2637518

产品详细信息

Immunogen sequence: AEWLGLLGDE QVPQAESILD ALSKHLVMKL SYGPEEKDMI VMRDSFGIRH PSGHLEHKTI DLVAYGDING FSAMAKTVGL PTAMAAKMLL DGEIGAKGLM GPFSKEIYGP ILERIKA

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

靶标信息

AASS is a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in the gene encoding this protein are associated with familial hyperlysinemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alpha-aminoadipate semialdehyde synthase; aminoadipic semialdehyde synthase; bifunctional enzyme; lysine-2-oxoglutarate reductase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; saccharopine dehydrogenase (NAD(+), L-glutamate-forming); saccharopine dehydrogenase (NADP(+), L-lysine-forming); unnamed protein product

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基因别名: LKR/SDH; LKRSDH; LORSDH

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UniProt ID: (Human) Q9UDR5

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Entrez Gene ID: (Human) 10157

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功能

transcription corepressor activity saccharopine dehydrogenase activity saccharopine dehydrogenase (NAD+, L-lysine-forming) activity histone binding saccharopine dehydrogenase (NADP+, L-lysine-forming) activity saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

参与通路

negative regulation of transcription from RNA polymerase II promoter L-lysine catabolic process