ABCB8 was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a internal portion of human ABCB8.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

80 mg/mL

保存液

0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

A BLAST analysis was used to suggest cross-reactivity with ABCB8 from human, mouse, and rat based on a 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known. The antibody detects ABCB8 in cell lysates.

靶标信息

This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ABCB8; ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 8; M-ABC1; mitochondrial ABC protein; Mitochondrial ATP-binding cassette 1; Mitochondrial potassium channel ATP-binding subunit; Mitochondrial sulfonylurea-receptor; MITOSUR

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基因别名: ABCB8; EST328128; M-ABC1; MABC1; MITOSUR

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UniProt ID: (Human) Q53GM0

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Entrez Gene ID: (Human) 11194

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功能

transporter activity ATP binding ATPase activity, coupled to transmembrane movement of substances ATP-binding cassette (ABC) transporter

参与通路

transport transmembrane transport