Search
Proteintech
ABCG1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
13578-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ABCG1 Fusion Protein Ag4479 (1-353 aa encoded by BC029158)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.24 mg/mL
规格
36 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MACLMAAFS VGTAMNASSY SAEMTEPKSV CVSVDEVVSS NMEATETDLL NGHLKKVDNN LTEAQRFSSL PRRAAVNIEF RDLSYSVPEG PWWRKKGYKT LLKGISGKFN SGELVAIMGP SGAGKSTLMN ILAGYRETGM KGAVLINGLP RDLRCFRKVS CYIMQDDMLL PHLTVQEAMM VSAHLKLQEK DEGRREMVKE ILTALGLLSC ANTRTGSLSG GQRKRLAIAL ELVNNPPVMF FDEPTSGLDS ASCFQVVSLM KGLAQGGRSI ICTIHQPSAK LFELFDQLYV LSQGQCVYRG KVCNLVPYLR DLGLNCPTYH NPADFVMEVA SGEYGDQNSR LVRAVREGMC DSDH (1-353 aa encoded by BC029158)
靶标信息
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ABC transporter 8; ABCG1p; ATP-binding cassette 8; ATP-binding cassette transporter 8; ATP-binding cassette transporter 8 (ABC8); ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette transporter, member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G (WHITE), member 1; homolog of Drosophila white; MGC34313; unnamed protein product; white; white protein homolog; white protein homolog (ATP-binding cassette transporter 8)
基因别名: ABC8; White; WHITE1
UniProt ID: (Human) P45844, (Mouse) Q64343
Entrez Gene ID: (Human) 9619, (Rat) 85264, (Mouse) 11307
protein binding
ATP binding
phospholipid binding
cholesterol binding
ATPase activity
toxin transporter activity
sterol-transporting ATPase activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
protein dimerization activity
phosphatidylcholine-translocating ATPase activity
intermembrane cholesterol transfer activity
floppase activity
ABC-type transporter activity
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
negative regulation of lipid storage
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
lipid translocation
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
positive regulation of protein secretion
transmembrane transport
phospholipid homeostasis
cellular response to high density lipoprotein particle stimulus
regulation of cholesterol metabolic process
positive regulation of beta-amyloid formation
drug transmembrane export
cholesterol transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
xenobiotic transport
positive regulation of secretory granule organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
