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Invitrogen
ABCG4 Polyclonal Antibody
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产品信息
PA5-50289
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein corresponding to residues near the N terminal of human ATP-binding cassette, sub-family G (WHITE), member 4
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total ABCG4 protein.
靶标信息
The ABCG4 gene encodes the ATP-binding cassette sub-family G member 4, a protein that is part of the ABC transporter family involved in the transport of various molecules across cellular membranes. ABC transporters play essential roles in lipid transport, drug resistance, and the maintenance of cellular homeostasis. ABCG4, specifically, is known to be involved in the transport of cholesterol and other lipids, influencing lipid homeostasis and potentially impacting processes such as cholesterol efflux and cellular lipid balance. This protein is expressed in specific tissues, including the brain and retina, indicating its role in neuronal lipid metabolism and health. While its exact physiological functions are still being elucidated, alterations in ABCG4 expression or function may be implicated in lipid-related disorders and neurodegenerative diseases, where lipid metabolism plays a crucial part. Research into ABCG4 focuses on understanding its transport mechanisms and potential contributions to pathological states, aiming to develop targeted therapies that address imbalances in lipid and cholesterol metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family G member 4; ATP-binding cassette subfamily G member 4; ATP-binding cassette transporter White2; ATP-binding cassette, sub-family G (WHITE), member 4; putative ABC transporter
基因别名: 6430517O04Rik; ABCG4; WHITE2
UniProt ID: (Human) Q9H172, (Mouse) Q91WA9
Entrez Gene ID: (Human) 64137, (Mouse) 192663
