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Abnova
ABI2 Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00010152-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ABI2 (NP_005750.4, 1 a.a. approximately 475 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAELQMLLEE EIPGGRRALF DSYTNLERVA DYCENNYIQS ADKQRALEET KAYTTQSLAS VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR THKIIAPANL ERPVRYIRKP IDYTILDDIG HGVKVSTQNM KMGGLPRTTP PTQKPPSPPM SGKGTLGRHS PYRTLEPVRP PVVPNDYVPS PTRNMAPSQQ SPVRTASVNQ RNRTYSSSGS SGGSHPSSRS SSRENSGSGS VGVPIAVPTP SPPSVFPGHP VQFYSMNRPA SRHTPPTIGG SLPYRRPPSI TSQTSLQNQM NGGPFYSQNP VSLAPPPPSI LQVTPQLPLM GFVARVQENI SDTPPPPPPV EEPVFDESPP PPPPPEDYEE EEAAVVEYSD PYAEEDPPWA PRSYLEKVVA IYDYTKDKED ELSFQEGAII YVIKKNDDGW YEGVMNGVTG LFPGNYVESI MHYSE
靶标信息
ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. ABI2 is a part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. It regulates ABL1/c-Abl-mediated phosphorylation of MENA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: abelson interactor 2; Abi-2b; abl binding protein 3; abl-interacting protein 1 (SH3-containing protein); abl-interactor protein 2b; arg protein tyrosine kinase-binding protein; arg-binding protein 1; unnamed protein product
基因别名: ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1; argBPIA; argBPIB; SSH3BP2
UniProt ID: (Human) Q9NYB9
Entrez Gene ID: (Human) 10152
mitophagy
neuron migration
cytoskeleton organization
actin polymerization or depolymerization
positive regulation of lamellipodium assembly
cell migration
Rac protein signal transduction
peptidyl-tyrosine phosphorylation
zonula adherens assembly
cell projection morphogenesis
regulation of dendritic spine morphogenesis
lens fiber cell morphogenesis
positive regulation of Arp2/3 complex-mediated actin nucleation
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