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Invitrogen
ACACA/ACACB Recombinant Rabbit Monoclonal Antibody (K01_4U11)
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产品信息
MA567796
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4U11
抗原
A synthesized peptide derived from human Acetyl-CoA Carboxylase.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 150mM NaCl, 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
ACACA and ACACB encode acetyl CoA carboxylase alpha and beta, the rate limiting enzymes that convert acetyl CoA to malonyl CoA for de novo fatty acid synthesis and regulation of fatty acid oxidation. ACACA is primarily cytosolic in lipogenic tissues such as liver and adipose, supporting fatty acid and triglyceride production, while ACACB is enriched in oxidative tissues such as heart and skeletal muscle, producing malonyl CoA near mitochondria to inhibit fatty acid entry via CPT1 and thereby modulate beta oxidation. Both enzymes are large biotin dependent carboxylases with biotin carboxylase, carboxyl transferase, and biotin carrier domains, and they are tightly controlled by phosphorylation through AMPK, by allosteric activation from citrate, by feedback from long chain acyl CoA species, and by transcriptional programs governed by SREBP1 and ChREBP. Genetic variation and dysregulation of ACACA and ACACB influence metabolic disorders including obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. Pharmacologic ACC inhibitors decrease malonyl CoA levels, reduce lipogenesis, and increase fatty acid oxidation, and are being developed for metabolic and liver indications. Detection and study use enzyme activity assays, metabolite profiling, immunoblotting, and CRISPR or RNA interference approaches.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACAC; acaca; ACACB-1; ACC-a; ACC-alpha; ACC-B; ACC-beta; ACC1; ACC2; ACCA; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 2; Acetyl-CoA carboxylase 265; acetyl-Coenzyme A carboxylase 2; Acetyl-Coenzyme A carboxylase alpha; acetyl-Coenzyme A carboxylase beta; unnamed protein product
基因别名: A530025K05Rik; ACAC; Acac1; ACACA; ACACAD; ACACalpha; ACACB; ACACbeta; ACC; ACC-beta; ACC1; ACC2; ACCA; ACCalpha; ACCB; ACCbeta; AI597064; AW743042; Gm738; hACC1; HACC275
UniProt ID: (Human) Q13085, (Human) O00763, (Mouse) Q5SWU9, (Rat) P11497, (Mouse) E9Q4Z2
Entrez Gene ID: (Human) 31, (Human) 32, (Mouse) 107476, (Rat) 60581, (Rat) 116719, (Mouse) 100705
tissue homeostasis
acetyl-CoA metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
metabolic process
response to organic cyclic compound
multicellular organismal protein metabolic process
protein homotetramerization
lipid homeostasis
cellular response to prostaglandin E stimulus
positive regulation of lipid storage
response to drug
negative regulation of fatty acid oxidation
positive regulation of heart growth
malonyl-CoA biosynthetic process
acyl-CoA metabolic process
lipid biosynthetic process
fatty-acyl-CoA biosynthetic process
pentose-phosphate shunt
purine nucleotide metabolic process
response to nutrient
response to xenobiotic stimulus
regulation of glucose metabolic process
fatty acid oxidation
response to nutrient levels
negative regulation of fatty acid beta-oxidation
glucose import
lactic acid secretion
negative regulation of lipid catabolic process
fatty acid homeostasis
response to caloric restriction
tricarboxylic acid metabolic process
intracellular aspartate homeostasis
glutamate homeostasis
energy homeostasis
regulation of cardiac muscle hypertrophy in response to stress
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