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Invitrogen
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Recommended positive controls: K562.
Predicted reactivity: Cow: 79%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Mouse: 79%; Rat: 79%; Yeast: 82%.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。