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Invitrogen
ACE Recombinant Rabbit Monoclonal Antibody (K01_1M75)
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产品信息
MA563309
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_1M75
抗原
Recombinant protein of mouse Angiotensin Converting Enzyme 1 (aa 636-1237).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PLPDNYPEGI DLETDEAKAD RFVEEYDRTA QVLLNEYAEA NWQYNTNITI EGSKILLEKS TEVSNHTLKY GTRAKTFDVS NFQNSSIKRI IKKLQNLDRA VLPPKELEEY NQILLDMETT YSLSNICYTN GTCMPLEPDL TNMMATSRKY EELLWAWKSW RDKVGRAILP FFPKYVEFSN KIAKLNGYTD AGDSWRSLYE SDNLEQDLEK LYQELQPLYL NLHAYVRRSL HRHYGSEYIN LDGPIPAHLL GNMWAQTWSN IYDLVAPFPS APNIDATEAM IKQGWTPRRI FKEADNFFTS LGLLPVPPEF WNKSMLEKPT DGREVVCHPS AWDFYNGKDF RIKQCTSVNM EDLVIAHHEM GHIQYFMQYK DLPVTFREGA NPGFHEAIGD IMALSVSTPK HLYSLNLLST EGSGYEYDIN FLMKMALDKI AFIPFSYLID QWRWRVFDGS ITKENYNQEW WSLRLKYQGL CPPVPRSQGD FDPGSKFHVP ANVPYVRYFV SFIIQFQFHE ALCRAAGHTG PLHKCDIYQS KEAGKLLADA MKLGYSKPWP EAMKLITGQP NMSASAMMNY FKPLTEWLVT ENRRHGETLG WPEYNWAPNT AR
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 94%, Pig - 81%, Cynomolgus monkey - 82%.
靶标信息
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACE; angiotensin 1 converting enzyme 1; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); Angiotensin-converting enzyme; CD143; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566
基因别名: Ace; AW208573; CD143; Dcp1; StsRR92
UniProt ID: (Mouse) P09470, (Rat) P47820
Entrez Gene ID: (Mouse) 11421, (Rat) 24310
actin binding
endopeptidase activity
carboxypeptidase activity
protein binding
drug binding
peptidase activity
metallopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
peptidyl-dipeptidase activity
zinc ion binding
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
hydrolase activity
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
metal ion binding
mitogen-activated protein kinase binding
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
metalloprotease
protease
protein modifying enzyme
kidney development
neutrophil mediated immunity
regulation of systemic arterial blood pressure by renin-angiotensin
positive regulation of systemic arterial blood pressure
proteolysis
peptide metabolic process
spermatogenesis
regulation of blood pressure
posttranscriptional regulation of gene expression
negative regulation of gene expression
bradykinin catabolic process
regulation of smooth muscle cell migration
sensory perception of pain
organ regeneration
negative regulation of protein binding
positive regulation of protein binding
response to lipopolysaccharide
vasoconstriction
hormone catabolic process
eating behavior
positive regulation of apoptotic process
peptide catabolic process
lung alveolus development
beta-amyloid metabolic process
arachidonic acid secretion
positive regulation of inflammatory response
positive regulation of neurogenesis
heart contraction
regulation of angiotensin metabolic process
angiogenesis involved in coronary vascular morphogenesis
positive regulation of protein tyrosine kinase activity
cell proliferation in bone marrow
negative regulation of calcium ion import
positive regulation of peptidyl-tyrosine autophosphorylation
regulation of hematopoietic stem cell proliferation
negative regulation of gap junction assembly
positive regulation of peptidyl-cysteine S-nitrosylation
response to hypoxia
brain development
female pregnancy
aging
male gonad development
lung development
response to nutrient levels
response to laminar fluid shear stress
response to drug
cellular response to glucose stimulus
response to dexamethasone
response to thyroid hormone
