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Invitrogen
ACY1 Polyclonal Antibody
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产品信息
PA1-27826
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to human Aminoacylase-1+E290.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
规格
50 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-27826 detects ACY1 from human, mouse, and rat samples.
PA1-27826 may be successfully used in Western blot applications. By Western blot, this antibody has only been tested on fusion protein.
The PA1-27645 immunogen is a synthetic peptide corresponding to human Aminoacylase-1+E290.
靶标信息
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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