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Invitrogen
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PA1-1743 detects ADAMTS15 in human samples. In Western blot analysis of lysate from 293EBNA cells transfected with a partial ADAMTS15 sequence, this antibody detects an ~50 kDa protein representing ADAMTS15.
The PA1-1743 immunogen is a synthetic peptide corresponding to residues C H(592) S T N R L T L A V A W(603) of human ADAMTS15.
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The immunizing peptide sequence is 100% conserved between human, mouse and rat.
仅用于科研。不用于诊断过程。未经明确授权不得转售。