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ADAP Polyclonal Antibody
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图: 1 / 3
ADAP Antibody (600-401-X71) in ICC/IF
Immunocytochemistry of ADAP antibody. Tissue: K562 cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: ADAP antibody at 10 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: ADAP is nuclear and cytoplasmic. Staining: ADAP as precipitated brown signal with hematoxylin purple counterstain.
产品信息
600-401-X71
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-ADAP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the N-terminus of human ADAP.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB-120/130; Fyb/SLAP2; FYB; T-cell and myeloid cell specific signaling substrate; FYN-binding protein 1; FYN-T-binding protein; p120/p130; predicted protein of HQ0823; SLAP-130; SLAP-130; 130 kDa; SLP-76-associated phosphoprotein; unnamed protein product
基因别名: ADAP; FYB; FYB1; PRO0823; SLAP-130; SLAP130; THC3
UniProt ID: (Human) O15117
Entrez Gene ID: (Human) 2533
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