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Invitrogen
AES Polyclonal Antibody
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产品信息
PA5-68937
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the C-terminal region of mouse AES
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This target displays homology in the following species: Cow: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%
靶标信息
Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amino-terminal enhancer of split; groucho-related protein 5; homologous to Drosophila groucho gene product and human TLE gene products; related to Drosophila groucho; unnamed protein product
基因别名: Aes; Esp1; Grg; Grg-5; Grg5
UniProt ID: (Mouse) P63002
Entrez Gene ID: (Mouse) 14797
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of gene expression
regulation of growth
negative regulation of transcription, DNA-templated
negative regulation of response to cytokine stimulus
response to interleukin-1
negative regulation of canonical Wnt signaling pathway
positive regulation of anoikis
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