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Invitrogen
ALDH1A2 Polyclonal Antibody
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ALDH1A2 Antibody (PA5-95364) in IHC (P)
Immunohistochemical analysis of ALDH1A2 in a paraffin-embedded section of human colorectal adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2 μg/mL rabbit anti-ALDH1A2 antibody (Product # PA5-95364) overnight at 4°C. Peroxidase Conjugated Goat... View More
产品信息
PA5-95364
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human ALDH1A2 recombinant protein (Position: M1-A110).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Human ALDH1A2 shares 95.5% amino acid (aa) sequence identity with both mouse and rat ALDH1A2.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human K562 whole cell, human 293T whole cell, human HepG2 whole cell, human Hela whole cell, rat kidney tissue, rat testis tissue, mouse kidney tissue, mouse testis tissue. IHC: human colorectal adenocarcinoma tissue, rat lung tissue. Flow: 293T cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AL1A2; alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase 1 family, member A2; aldehyde dehydrogenase 1A2; Aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ALDH1A2; RALDH 2; RALDH(II); ralDH2; Retinal dehydrogenase 2; retinal dehydrogenase, type II; retinaldehyde dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2
基因别名: ALDH1A2; Aldh1a7; AV116159; RALDH(II); Raldh-2; Raldh1; RALDH2; RALDH2-T
UniProt ID: (Human) O94788, (Mouse) Q62148, (Rat) Q63639
Entrez Gene ID: (Human) 8854, (Mouse) 19378, (Rat) 116676
retinal dehydrogenase activity
3-chloroallyl aldehyde dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
retinal binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
blood vessel development
kidney development
liver development
regulation of endothelial cell proliferation
retinoic acid biosynthetic process
heart morphogenesis
vitamin A metabolic process
midgut development
positive regulation of cell proliferation
negative regulation of cell proliferation
determination of bilateral symmetry
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of gene expression
neural crest cell development
morphogenesis of embryonic epithelium
neural tube development
pituitary gland development
neuron differentiation
lung development
hindbrain development
pancreas development
embryonic camera-type eye development
response to estradiol
response to vitamin A
response to cytokine
embryonic forelimb morphogenesis
ureter maturation
retinol metabolic process
retinoic acid metabolic process
retinal metabolic process
9-cis-retinoic acid biosynthetic process
positive regulation of apoptotic process
retinoic acid receptor signaling pathway
embryonic digestive tract development
cardiac muscle tissue development
oxidation-reduction process
face development
cellular response to retinoic acid
retinoid metabolic process
heart looping
heart development
metabolic process
embryonic limb morphogenesis
forebrain development
camera-type eye development
