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Proteintech
ALKBH5 Recombinant Rabbit Monoclonal Antibody (2K9)
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产品信息
82083-1-RR
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Mammalian cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2K9
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: KRKYQEDSDP ERSDYEEQQL QKEEEARKVK SGIRQMRLFS QDECAKIEAR IDEVVSRAEK GLYNEHTVDR APLRNKYFFG EGYTYGAQLQ KRGPGQERLY PPGDVDEIPE WVHQLVIQKL VEHRVIPEGF VNSAVINDYQ PGGCIVSHVD PIHIFERPIV SVSFFSDSAL CFGCKFQFKP IRVSEPVLSL PVRRGSVTVL SGYAADEITH CIRPQDIKER RAVIILRKTR LDAPRLETKS LSSSVLPPSY ASDRLSGNNR DPALKPKRSH RKADPDAAHR PRILEMDKEE NRRSVLLPTH RRRGSFSSEN YWRKSYESSE DCSEAAG
靶标信息
ALKBH5 (RNA demehtylase ALKBH5) is a dioxygenase that demethylates RNA by oxidative demethylation. Specifically, it demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylation of m6A mRNA affects mRNA processing and export. ALKBH5 can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). It requires molecular oxygen, alpha-ketoglutarate and iron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AlkB family member 5, RNA demethylase; alkB, alkylation repair homolog 5; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RNA demethylase ALKBH5
基因别名: ABH5; ALKBH5; AW050020; AW215868; E130207K11; OFOXD; OFOXD1; RGD1309496
UniProt ID: (Human) Q6P6C2, (Mouse) Q3TSG4, (Rat) D3ZKD3
Entrez Gene ID: (Human) 54890, (Mouse) 268420, (Rat) 303193
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
oxidative RNA demethylase activity
poly(A) RNA binding
metal ion binding
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
RNA processing factor
