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Invitrogen
ALKBH5 Recombinant Rabbit Monoclonal Antibody (2S4Q6)
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ALKBH5 Antibody (MA5-51412) in IHC (P)
Immunohistochemistry analysis of ALKBH5 in paraffin-embedded Human kidney. Samples were incubated with ALKBH5 Recombinant monoclonal antibody (Product # MA5-51412) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
MA5-51412
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2S4Q6
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 66-394 of human ALKBH5 (NP_060228.3).
偶联物
形式
Liquid
浓度
0.08 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PERSDYEEQQ LQKEEEARKV KSGIRQMRLF SQDECAKIEA RIDEVVSRAE KGLYNEHTVD RAPLRNKYFF GEGYTYGAQL QKRGPGQERL YPPGDVDEIP EWVHQLVIQK LVEHRVIPEG FVNSAVINDY QPGGCIVSHV DPIHIFERPI VSVSFFSDSA LCFGCKFQFK PIRVSEPVLS LPVRRGSVTV LSGYAADEIT HCIRPQDIKE RRAVIILRKT RLDAPRLETK SLSSSVLPPS YASDRLSGNN RDPALKPKRS HRKADPDAAH RPRILEMDKE ENRRSVLLPT HRRRGSFSSE NYWRKSYESS EDCSEAAGSP ARKVKMRRH
靶标信息
ALKBH5 (RNA demehtylase ALKBH5) is a dioxygenase that demethylates RNA by oxidative demethylation. Specifically, it demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylation of m6A mRNA affects mRNA processing and export. ALKBH5 can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). It requires molecular oxygen, alpha-ketoglutarate and iron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AlkB family member 5, RNA demethylase; alkB, alkylation repair homolog 5; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RNA demethylase ALKBH5
基因别名: ABH5; ALKBH5; AW050020; AW215868; E130207K11; OFOXD; OFOXD1; RGD1309496
UniProt ID: (Human) Q6P6C2, (Mouse) Q3TSG4, (Rat) D3ZKD3
Entrez Gene ID: (Human) 54890, (Mouse) 268420, (Rat) 303193
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
oxidative RNA demethylase activity
poly(A) RNA binding
metal ion binding
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
RNA processing factor
