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Proteintech
AMHR2 Polyclonal Antibody
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产品信息
25888-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AMHR2 fusion protein Ag22473
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: KLVAIKAFPP RSVAQFQAER ALYELPGLQH DHIVRFITAS RGGPGRLLSG PLLVLELHPK GSLCHYLTQY TSDWGSSLRM ALSLAQGLAF LHEERWQNGQ YKPGIAHRDL SSQNVLIRED GSCAIGDLGL ALVLPGLTQP PAWTPTQPQG PAAIMEAGTQ RYMAPELLDK TLDLQDWGMA LRRADIYSLA LLLWEILSRC PDLRPDSSPP PFQLAYEAEL GNTPTSDELW ALAVQERRRP YIPSTWRCFA TDPDGLRELL EDCWDADPEA RLTAECVQQR LAALAHPQES HPFPESCPRG CPPLCPEDCT SIPAPTILPC RPQRSACHFS VQQGPCSRNP QPACTLSPV
靶标信息
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMH type II receptor; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor type II; anti-Mullerian hormone receptor, type II; anti-Mullerian hormone type 2 receptor delta 2; anti-Mullerian hormone type 2 receptor delta 9/10; MIS type II receptor; MISRII; Muellerian inhibiting substance type II receptor; Mullerian inhibiting substance type II receptor
基因别名: AMHR; AMHR2; Misiir; MISR2; MISRII; MRII
UniProt ID: (Human) Q16671, (Mouse) Q8K592
Entrez Gene ID: (Human) 269, (Mouse) 110542
receptor signaling protein serine/threonine kinase activity
receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
hormone binding
metal ion binding
anti-Mullerian hormone receptor activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
Mullerian duct regression
signal transduction
transforming growth factor beta receptor signaling pathway
sex differentiation
male gonad development
female gonad development
signal transduction by protein phosphorylation
negative regulation of anti-Mullerian hormone signaling pathway
anti-Mullerian hormone signaling pathway
protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
G-protein coupled receptor signaling pathway
phosphorylation
