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Proteintech
ANTXR1 Polyclonal Antibody
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产品信息
15091-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ANTXR1 Fusion Protein Ag4626 (1-318 aa encoded by BC012074)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MATAERRAL GIGFQWLSLA TLVLICAGQG GRREDGGPAC YGGFDLYFIL DKSGSVLHHW NEIYYFVEQL AHKFISPQLR MSFIVFSTRG TTLMKLTEDR EQIRQGLEEL QKVLPGGDTY MHEGFERASE QIYYENRQGY RTASVIIALT DGELHEDLFF YSEREANRSR DLGAIVYCVG VKDFNETQLA RIADSKDHVF PVNDGFQALQ GIIHSILKKS CIEILAAEPS TICAGESFQV VVRGNGFRHA RNVDRVLCSF KINDSVTLNE KPFSVEDTYL LCPAPILKEV GMKAALQVSM NDGLSFISSS VIITTTHCS (1-318 aa encoded by BC012074 )
靶标信息
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8
基因别名: 2310008J16Rik; 2810405N18Rik; Antrx1; ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2, (Rat) Q0PMD2, (Mouse) Q9CZ52
Entrez Gene ID: (Human) 84168, (Rat) 362393, (Mouse) 69538
