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Invitrogen
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PA1-5890 detects APPL1 in human and mouse samples.
PA1-5890 has been successfully used in immunofluorescence, immunohistochemistry (Frozen) and western blotting.
The PA1-5890 immunogen is purified APPL1 fusion protein.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signaling and insulin signaling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。