Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Osenses
AQP0 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
OSA00180W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Guinea pig,
Mouse,
Rat
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 210-263 of mouse AQP0 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and guinea pig.
Specificity of this antibody: AQP0.
靶标信息
AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: aquaporin 0; Aquaporin-0; Aquaporin0; dominant cataract; hydropic fibers; Lens fiber major intrinsic protein; lens opacity; major intrinsic protein 26; MIP 26; MP26; major intrinsic protein of eye lens fiber; MIP26; MP26
基因别名: AQP0; Cat; Hfi; Lop; Mip; MIP26; Palm; shrivelled; Svl
UniProt ID: (Mouse) P51180, (Rat) P09011
Entrez Gene ID: (Mouse) 17339, (Guinea pig) 100135575, (Rat) 25480
