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Proteintech
ARAP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
25143-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ARAP2 Fusion Protein Ag18469 (1356-1704 aa encoded by BC105089)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.43 mg/mL
规格
64.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LTNDILAIK NIIPTKGDIW ATFEVIENEE LERPLHYKEN VLEQVLRWSS LAEPGSAYLV VKRFLTADTI KHCSDRSTLG SIKEGILKIK EEPSKILSGN KFQDRYFVLR DGFLFLYKDV KSSKHDKMFS LSSMKFYRGV KKKMKPPTSW GLTAYSEKHH WHLCCDSSQT QTEWMTSIFI AQHEYDIWPP AGKERKRSIT KNPKIGGLPL IPIQHEGNAT LARKNIESAR AELERLRLSE KCDKESVDSS LKERASMVAH CLEHKDDKLR NRPRKHRSFN CLEDTEPEAP LGQPKGHKGL KTLRKTEDRN SKATLDSDHK LPSRVIEELN VVLQRSRTLP KELQDEQILK (1356-1704 aa encoded by BC105089)
靶标信息
ARAP2 also known as Centaurin-delta-1 is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3, 4, 5-trisphosphate-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) binding and can be activated by phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4, 5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arf and Rho GAP adapter protein 2; centaurin; centaurin, delta 1; centaurin-delta-1; cnt-d1; contains RhoGAP and ARFGAP; KIAA0580; PARX protein; unnamed protein product
基因别名: CENTD1; Gm148; mKIAA0580; PARX
UniProt ID: (Human) Q8WZ64
Entrez Gene ID: (Human) 116984, (Mouse) 212285, (Rat) 305367
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