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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: RYPTHFLSTN SVLASVTASL KEHPRGTLLS DGSPALSRNV GMTVSQKGGP QPTPSPAGPG TQLGPITGEM DEADSAFLKF KQTADDSLSL TSPNTESI
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 68%.
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 114 kDa Rho-specific guanine nucleotide exchange factor; Rho-specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; septin-associated RhoGEF; unnamed protein product
基因别名: P114-RhoGEF; p114RhoGEF; RP78; SA-RhoGEF
UniProt ID: (Human) Q6ZSZ5
Entrez Gene ID: (Human) 23370