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Invitrogen
ATIC Polyclonal Antibody
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ATIC Antibody (PA5-117021) in WB
Western blot analysis of ATIC in extracts of various cell lines. Samples were incubated with ATIC Polyclonal antibody (Product # PA5-117021) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-117021
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ATIC (NP_0040352)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: MCF7, SW480, NCI-H460, HepG2, SW620, HT-29, K-562
Immunogen sequence: MAPGQLALFS VSDKTGLVEF ARNLTALGLN LVASGGTAKA LRDAGLAVRD VSELTGFPEM LGGRVKTLHP AVHAGILARN IPEDNADMAR LDFNLIRVVA CNLYPFVKTV ASPGVTVEEA VEQIDIGGVT LLRAAAKNHA RVTVVCEPED YVVVSTEMQS SESKDTSLET RRQLALKAFT HTAQYDEAIS DYFRKQYSKG VSQMPLRYGM NPHQTPAQLY TLQPKLPITV LNGAPGFINL CDALNAWQLV KELKEALGIP AAASFKHVSP AGAAVGIPLS EDEAKVCMVY DLYKTLTPIS
靶标信息
ATIC is a 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase which helps catalyze the penultimate and final steps of the de novo purine biosynthetic pathway. The human ATIC cDNA encodes a deduced 591-amino acid protein that is 81% identical to the chicken sequence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase/inosine monophosphate cyclohydrolase; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein ATIC; epididymis secretory sperm binding protein Li 70p; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
基因别名: AICAR; AICARFT; ATIC; HEL-S-70p; IMPCHASE; OK/SW-cl.86; PURH
UniProt ID: (Human) P31939
Entrez Gene ID: (Human) 471
brainstem development
nucleobase-containing compound metabolic process
'de novo' IMP biosynthetic process
nucleoside metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to inorganic substance
cerebellum development
cerebral cortex development
organ regeneration
dihydrofolate metabolic process
tetrahydrofolate biosynthetic process
cell-cell adhesion
