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Proteintech
ATN1 Polyclonal Antibody
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产品信息
19243-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ATN1 Fusion Protein Ag5835 (842-1191 aa encoded by BC051795)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LAQEGRAPV ECPSLGPVPH RPPFEPGSAV ATVPPYLGPD TPALRTLSEY ARPHVMSPGN RNHPFYVPLG AVDPGLLGYN VPALYSSDPA AREREREARE RDLRDRLKPG FEVKPSELEP LHGVPGPGLD PFPRHGGLAL QPGPPGLHPF PFHPSLGPLE RERLALAAGP ALRPDMSYAE RLAAERQHAE RVAALGNDPL ARLQMLNVTP HHHQHSHIHS HLHLHQQDAI HAASASVHPL IDPLASGSHL TRIPYPAGTL PNPLLPHPLH ENEVLRHQLF AAPYRDLPAS LSAPMSAAHQ LQAMHAQSAE LQRLALEQQQ WLHAHHPLHS VPLPAQEDYY SHLKKESDKP L (842-1191 aa encoded by BC051795)
靶标信息
Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Atrophin-1; Atrophin1; dentatorubral pallidoluysian atrophy; Dentatorubral-pallidoluysian atrophy protein; Dentatorubral-pallidoluysian atrophy protein homolog
基因别名: ATN1; Atr1; atrophin-1; B37; D12S755E; DRPLA; HRS; NOD
UniProt ID: (Human) P54259, (Mouse) O35126
Entrez Gene ID: (Human) 1822, (Mouse) 13498
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
toxin metabolic process
cell migration
maintenance of cell polarity
positive regulation of transcription from RNA polymerase II promoter
neuron apoptotic process
negative regulation of nucleic acid-templated transcription
central nervous system development
