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ATP13A2 Monoclonal Antibody (4B7)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00023400-M06
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B7
抗原
ATP13A2 (NP_071372, 68 a.a. approximately 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.43 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: KPLWGVRLRL RPCNLAHAET LVIEIRDKED SSWQLFTVQV QTEAIGEGSL EPSPQSQAED GRSQAAVGAV PEGAWKDTAQ LHKSEEA
靶标信息
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT132 antibody; ATPase 13A2; ATPase type 13A2; cation-transporting ATPase 13A2; HSA9947 antibody; probable cation-transporting ATPase 13A2; putative ATPase; RP1-37C10.4; unnamed protein product
基因别名: CLN12; HSA9947; KRPPD; PARK9; SPG78
UniProt ID: (Human) Q9NQ11
Entrez Gene ID: (Human) 23400
nucleotide binding
protein binding
ATP binding
zinc ion binding
polyamine transmembrane transporter activity
polyamine-transporting ATPase activity
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
ATPase activity
cation-transporting ATPase activity
manganese ion binding
phosphatidic acid binding
phosphatidylinositol-3,5-bisphosphate binding
P-type transmembrane transporter activity
cupric ion binding
cellular calcium ion homeostasis
cellular iron ion homeostasis
cellular zinc ion homeostasis
autophagy
lysosomal transport
positive regulation of gene expression
regulation of mitochondrion organization
regulation of macroautophagy
regulation of autophagosome size
cellular cation homeostasis
regulation of intracellular protein transport
ion transmembrane transport
cellular response to oxidative stress
regulation of neuron apoptotic process
positive regulation of protein secretion
lipid homeostasis
protein localization to lysosome
autophagosome-lysosome fusion
cellular response to manganese ion
cellular response to zinc ion
extracellular exosome biogenesis
cation transmembrane transport
regulation of protein localization to nucleus
polyamine transmembrane transport
regulation of mitophagy
positive regulation of exosomal secretion
spermine transmembrane transport
regulation of chaperone-mediated autophagy
autophagosome organization
regulation of lysosomal protein catabolic process
negative regulation of lysosomal protein catabolic process
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