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ATP1A1/2 Monoclonal Antibody (3D8G1)

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ATP1A1/2 Monoclonal Antibody (3D8G1)

产品信息

68505-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000-1:50,000
-

免疫细胞化学 (ICC/IF)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Pig, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3D8G1

抗原

ATP1A1/2 fusion protein Ag10489
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

规格

75 µg

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH EADTTEDQSG ATFDKRSPTW TALSRIAGLC NRAVFKAGQE NISVSKRDTA GDASESALLK CIELSCGSVR KMRDRNPKVA EIPFNSTNKY QLSIHEREDS PQSHVLVMKG APERILDRCS TILVQGKEIP LDKEMQDAFQ NAYMELGGLG ERVLGFCQLN LPSGKFPRGF KFDTDELNFP TEKLCFVGLM SMIDPPRAAV PDAVGKCRSA GIKVIMVTGD HPITAKAIAK GVGIISEGNE TVEDIAARLN IPMSQVNPRE AKACVVHGSD LKDMTSEQLD EILKNHTEIV FARTSPQQKL IIVE

靶标信息

ATP1A1/2 is the catalytic component of the active enzyme Na+/K+-ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. The Na+/K+-ATPase is composed of a larger catalytic alpha-subunit (~110 kDa) and a small beta-subunit (~55 kDa). The alpha subunit has four isoforms identified to date: alpha 1, alpha 2, alpha 3 and alpha 4.The alpha 1 isoform is expressed ubiquitously but the alpha 2 isoform is present largely in the skeletal muscle, heart and vascular smooth muscle. The alpha 3 isoform is found almost exclusively in neurons and ovaries. The alpha 4 isoform is expressed in sperm.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: (Na+ and K+) ATPase, alpha catalytic subunit precursor; (Na+ and K+) ATPase, alpha+ catalytic subunit precursor; (Na+, K+)-ATPase alpha-subunit; ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 1; ATPase, Na+K+ transporting, alpha 2; G00-119-711; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-1 subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+ ,K+ -ATPase alpha subunit; Na+ /K+ ATPase alpha 1 subunit; Na+ K+ ATPase alpha subunit; Na+, K+-ATPase beta-subunit precursor; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ transporting alpha 1 polypeptide; Na+/K+ transporting alpha 2 polypeptide; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha 2 subunit; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na,K-ATPase subunit alpha-B; Na,K-ATPase, alpha-subunit; sodium pump subunit alpha-1; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium-ATPase, alpha 1 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; unnamed protein product

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基因别名: Atpa-1; Atpa-3; CMT2DD; DEE98; FARIMPD; FHM2; HOMGSMR2; MHP2; mKIAA0778; Nkaa1b; RATATPA2

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UniProt ID: (Human) P05023, (Pig) P05024, (Human) P50993, (Pig) D2WKD8, (Mouse) Q8VDN2, (Rat) P06685, (Mouse) Q6PIE5, (Rat) P06686

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Entrez Gene ID: (Human) 476, (Pig) 397481, (Human) 477, (Pig) 396828, (Mouse) 11928, (Rat) 24211, (Mouse) 98660, (Rat) 24212

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功能
nucleotide binding sodium:potassium-exchanging ATPase activity protein binding ATP binding potassium-transporting ATPase activity phosphatase activity ATPase activity potassium ion binding sodium ion binding ion channel binding chaperone binding steroid hormone binding ATPase binding steroid binding cation-transporting ATPase activity protein heterodimerization activity protein kinase binding protein domain specific binding ankyrin binding ADP binding phosphatidylinositol 3-kinase binding primary active transporter transporter
参与通路
regulation of sodium ion transport potassium ion transport cellular sodium ion homeostasis osmosensory signaling pathway establishment or maintenance of transmembrane electrochemical gradient cellular cation homeostasis cellular potassium ion homeostasis sodium ion transmembrane transport sodium ion export from cell sodium ion homeostasis relaxation of cardiac muscle cellular response to steroid hormone stimulus potassium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction hydrogen ion transmembrane transport response to glycoside potassium ion import across plasma membrane transmembrane transport neurotransmitter uptake behavioral fear response regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process sodium ion transport regulation of muscle contraction regulation of striated muscle contraction cell communication blood circulation regulation of heart contraction regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion response to auditory stimulus amygdala development olfactory cortex development response to nicotine locomotory exploration behavior locomotion negative regulation of heart contraction positive regulation of heart contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic cardiac muscle contraction cellular response to mechanical stimulus regulation of cardiac muscle cell contraction membrane depolarization during cardiac muscle cell action potential cation transmembrane transport transport across blood-brain barrier negative regulation of calcium ion transmembrane transport regulation of blood pressure response to xenobiotic stimulus negative regulation of glucocorticoid biosynthetic process positive regulation of striated muscle contraction membrane hyperpolarization energy coupled proton transmembrane transport, against electrochemical gradient regulation of smooth muscle contraction adult locomotory behavior visual learning response to mechanical stimulus neuronal action potential propagation regulation of vasoconstriction L-ascorbic acid metabolic process response to potassium ion fear response negative regulation of striated muscle contraction membrane depolarization regulation of cardiac muscle contraction by calcium ion signaling
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