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          • Primary Antibodies ›
          • ATP1A2/ATP1A3 Antibodies

          Osenses

          ATP1A2/ATP1A3 Polyclonal Antibody

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          Cite ATP1A2/ATP1A3 Polyclonal Antibody

          Additional Information:
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          ATP1A2/ATP1A3 Polyclonal Antibody

          产品信息

          OSA00277W-100UL

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:300-1:2,000
          -

          免疫组化 (IHC)

          1:300-1:2,000
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / Ig

          分类

          Polyclonal

          类型

          Antibody

          抗原

          A synthetic peptide from aa region 970-1013 of human ATP1A3 conjugated to blue carrier protein was used as the antigen
          3D表位/免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Lyophilized

          浓度

          Conc. Not Determined

          保存液

          whole serum

          内含物

          no preservative

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

          The peptide is homologous in rat and mouse and shares 95% identity with rat and mouse ATP1A2 sequences.

          Specificity of this antibody: ATP1A3 and ATP1A2.

          靶标信息

          The protein encoded by these genes belong to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes [provided by RefSeq, Oct 2008]

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 3 subunit; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ -ATPase alpha 3 subunit; Na+/K+ ATPase 3; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na,K-ATPase subunit alpha-B; Sodium pump subunit alpha-2; Sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-2; Sodium/potassium-transporting ATPase subunit alpha-3; unnamed protein product

          查看更多 收起

          基因别名: AHC2; ATP1A1; ATP1A2; ATP1A3; Atpa-2; Atpa-3; Atpa1a3; AW060654; CAPOS; DEE98; DEE99; DYT12; FARIMPD; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2; RDP

          查看更多 收起

          UniProt ID: (Human) P50993, (Human) P13637, (Rat) P06686, (Mouse) Q6PIE5, (Rat) P06687, (Mouse) Q6PIC6

          查看更多 收起

          Entrez Gene ID: (Human) 477, (Human) 478, (Rat) 24212, (Mouse) 98660, (Rat) 24213, (Mouse) 232975

          查看更多 收起

          功能
          nucleotide binding sodium:potassium-exchanging ATPase activity steroid binding protein binding ATP binding potassium-transporting ATPase activity phosphatase activity ATPase activity cation-transporting ATPase activity potassium ion binding sodium ion binding metal ion binding protein heterodimerization activity chaperone binding steroid hormone binding beta-amyloid binding hydrolase activity D1 dopamine receptor binding heparan sulfate proteoglycan binding sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential primary active transporter
          参与通路
          neurotransmitter uptake behavioral fear response regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of muscle contraction regulation of smooth muscle contraction regulation of striated muscle contraction cell communication blood circulation regulation of heart contraction regulation of blood pressure adult locomotory behavior visual learning establishment or maintenance of transmembrane electrochemical gradient regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion response to auditory stimulus neuronal action potential propagation regulation of vasoconstriction L-ascorbic acid metabolic process amygdala development olfactory cortex development cellular cation homeostasis cellular potassium ion homeostasis response to nicotine locomotory exploration behavior sodium ion transmembrane transport response to potassium ion sodium ion export from cell locomotion fear response negative regulation of heart contraction positive regulation of heart contraction negative regulation of striated muscle contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration membrane depolarization regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic relaxation of cardiac muscle cardiac muscle contraction cellular response to mechanical stimulus cellular response to steroid hormone stimulus potassium ion transmembrane transport regulation of cardiac muscle cell contraction membrane repolarization membrane depolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction cation transmembrane transport transport across blood-brain barrier hydrogen ion transmembrane transport negative regulation of calcium ion transmembrane transport response to glycoside potassium ion import across plasma membrane regulation of resting membrane potential cellular response to beta-amyloid neuron projection maintenance metabolic process potassium ion import regulation of cardiac muscle contraction by calcium ion signaling energy coupled proton transmembrane transport, against electrochemical gradient ATP hydrolysis coupled proton transport negative regulation of calcium:sodium antiporter activity transport memory ionotropic glutamate receptor signaling pathway response to drug regulation of cardiac muscle cell membrane potential
          It has to be done as per old AB suggested Products section.

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