Invitrogen

Akirin2 Polyclonal Antibody

Name: Akirin2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-34875

查看其他6个AKIRIN2抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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Akirin2 Antibody (PA5-34875) in WB

Western Blot using Akirin2 Polyclonal Antibody (Product # PA5-34875). Sample (30 µg of whole cell lysate). Lane A: HeLa. 12% SDS PAGE. Akirin2 Polyclonal Antibody (Product # PA5-34875) diluted at 1:10,000.

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产品信息

PA5-34875

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:5,000-1:20,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human Akirin 2. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2552227

产品详细信息

Recommended positive controls: A549, HeLa, HCT116.

Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (81%), Xenopus laevis (83%), Pig (98%), Chicken (94%), Sheep (97%), Chimpanzee (100%), Bovine (97%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。