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Proteintech
Alpha adducin Polyclonal Antibody
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产品信息
10791-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Alpha adducin Fusion Protein Ag1245 (1-400 aa encoded by BC013393)
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MNGDSRAAV VTSPPPTTAP HKERYFDRVD ENNPEYLRER NMAPDLRQDF NMMEQKKRVS MILQSPAFCE ELESMIQEQF KKGKNPTGLL ALQQIADFMT TNVPNVYPAA PQGGMAALNM SLGMVTPVND LRGSDSIAYD KGEKLLRCKL AAFYRLADLF GWSQLIYNHI TTRVNSEQEH FLIVPFGLLY SEVTASSLVK INLQGDIVDR GSTNLGVNQA GFTLHSAIYA ARPDVKCVVH IHTPAGAAVS AMKCGLLPIS PEALSLGEVA YHDYHGILVD EEEKVLIQKN LGPKSKVLIL RNHGLVSVGE SVEEAFYYIH NLVVACEIQV RTLASAGGPD NLVLLNPEKY KAKSRSPGSP VGEGTGSPPK WQIGEQEFEA LMRMLDNLGY RTSSSGRRQD G (1-400 aa encoded by BC013393)
靶标信息
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; alpha-ADD; Alpha-adducin; beta Adducin; Beta-adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha
基因别名: ADD1; ADDA; AI256389
UniProt ID: (Human) P35611, (Mouse) Q9QYC0, (Rat) Q63028
Entrez Gene ID: (Human) 118, (Mouse) 11518, (Rat) 24170
actin binding
structural molecule activity
calmodulin binding
transcription factor binding
spectrin binding
protein homodimerization activity
poly(A) RNA binding
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion
T cell receptor binding
protein binding
non-motor actin binding protein
cell morphogenesis
in utero embryonic development
cell volume homeostasis
hemoglobin metabolic process
actin cytoskeleton organization
erythrocyte differentiation
positive regulation of protein binding
multicellular organism growth
IRE1-mediated unfolded protein response
homeostasis of number of cells within a tissue
barbed-end actin filament capping
actin filament bundle assembly
transmembrane transport
cell-cell adhesion
negative regulation of actin filament polymerization
positive regulation of angiogenesis
positive regulation of endocytosis
cellular response to retinoic acid
ion transport
cytoskeleton organization
