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Invitrogen
ApoC3 Polyclonal Antibody
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图: 1 / 4
ApoC3 Antibody (PA5-78802) in IHC (P)
Immunohistochemistry (Paraffin) analysis of ApoC3 in paraffin-embedded section of mouse liver tissue using ApoC3 Polyclonal Antibody (Product # PA5-78802). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight at 4°C.... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78802
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human Apolipoprotein CIII recombinant protein (Position: S21-A99).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human hepatocellular carcinoma tumor tissue, human hepatocellular carcinoma paracancerous tissue. IHC: mouse liver tissue. Flow: HepG2 cell.
靶标信息
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Apo-CIII; Apolipoprotein; Apolipoprotein C-III; apolipoprotein C-III precursor; Apolipoprotein C3; MGC150353; unnamed protein product
基因别名: Apo-C3; apo-CIII; ApoC-3; apoC-III; APOC3; APOCIII
Entrez Gene ID: (Human) 345, (Mouse) 11814
triglyceride metabolic process
triglyceride mobilization
lipid transport
G-protein coupled receptor signaling pathway
cholesterol metabolic process
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
triglyceride catabolic process
regulation of Cdc42 protein signal transduction
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle remodeling
chylomicron remnant clearance
lipoprotein metabolic process
cholesterol homeostasis
lipoprotein transport
response to peptide hormone
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of cholesterol import
triglyceride homeostasis
cellular response to glucose stimulus
negative regulation of oxidative phosphorylation
very-low-density lipoprotein particle assembly
reverse cholesterol transport
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
