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Bioss
Apoptosis enhancing nuclease Polyclonal Antibody
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产品信息
BS-7604R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human Apoptosis enhancing nuclease, amino acids 1-100.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aen {ECO:0000250|UniProtKB:Q8WTP8}; Apoptosis-enhancing nuclease; apoptosis-enhancing nuclease {ECO:0000250|UniProtKB:Q8WTP8}; interferon stimulated exonuclease gene 20-like 1; interferon stimulated exonuclease gene 20kDa-like 1; Interferon-stimulated 20 kDa exonuclease-like 1; interferon-stimulated 20 kDa exonuclease-like 1 {ECO:0000312|RGD:1305051}
基因别名: 2700083B06Rik; AEN; ISG20L1; pp12744; RGD1305051; SBBI58
UniProt ID: (Human) Q8WTP8, (Rat) B2GUW6, (Mouse) Q9CZI9
Entrez Gene ID: (Human) 64782, (Rat) 361594, (Mouse) 68048
