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Invitrogen
Ataxin 2 Polyclonal Antibody
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FIGURE: 1 / 8
Ataxin 2 Antibody (PA5-146310) in IHC
Immunohistochemical staining of Ataxin 2 in human colon, kidney, skeletal muscle and testis using Ataxin 2 Polyclonal Antibody (Product # PA5-146310) (A) shows similar protein distribution across tissues to an independent Ataxin 2 Polyclonal Antibody (B).
Product Details
PA5-146310
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Ataxin 2
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RHPRNHRVSA GRGSISSGLE FVSHNPPSEA ATPPVARTSP SGGTWSSVVS GVPRLSPKTH RPRSPRQNSI GNTPSGPVLA SPQAGIIPTE AVAMPIPAAS PTPASPASNR AVTPSSEAKD SRLQDQRQNS PAGNKENIKP NET
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ataxin-2; FLJ46772; Spinocerebellar ataxia type 2 protein; Trinucleotide repeat-containing gene 13 protein
Gene Aliases: ASL13; ATX2; ATXN2; SCA2; TNRC13
UniProt ID: (Human) Q99700
Entrez Gene ID: (Human) 6311
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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