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Invitrogen
Ataxin 7 Monoclonal Antibody (3SCA-1C1)
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图: 1 / 2
Ataxin 7 Antibody (MA3-083) in ICC/IF
Immunofluorescent analysis of Ataxin 7 (green) in Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.1% Triton X-100 in PBS for 15 minutes, and blocked with 3% BSA in PBS (Product # 37525) for 30 minutes at room temperature. Cells were stained with a Ataxin 7 mouse monoclonal antibody (Product # MA3-083) at a dilution of 1:50 in staining buffer for 1 hour at room temperature, and then incubated with a Goat anti-Mouse IgG Superclonal™ Secondary Antibody, Alexa Fluor 488 conjugate (Product # A281... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA3-083
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3SCA-1C1
抗原
Recombinant human Ataxin 7 aa 1 - 229.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA3-083 detects Ataxin 7 from human and mouse samples.
MA3-083 has been successfully used in Western blot, immunofluorescence, and ELISA applications.
The MA3-083 epitope is mapped between aa 66 and aa 119.
靶标信息
Spinocerebellar ataxia type 7 (SCA7) belongs to a class of hereditary neurodegenrative diseases characterized by abnormally expanded polyglutamine (CAG) repeats at the N-terminus. This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem and causes dementia, macular degeneration and other neurodegenerative characteristics. SCA7 gene encodes the ubiquitous 892 residue protein ataxin-7. This protein is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autosomal dominant cerebellar ataxia with retinal degeneration; SAGA associated factor 73 kDa homolog; spinocerebellar ataxia 7 homolog; spinocerebellar ataxia type 7 protein; spinocerebellar ataxia type 7 protein homolog; spinocerebellar ataxia type 7; SCA7; unnamed protein product
基因别名: A430107N12Rik; ADCAII; ataxin-7; OPCA3; SCA7; SGF73
UniProt ID: (Human) O15265, (Mouse) Q8R4I1
Entrez Gene ID: (Human) 6314, (Mouse) 246103
microtubule cytoskeleton organization
regulation of DNA repair
regulation of transcription from RNA polymerase II promoter
negative regulation of microtubule depolymerization
negative regulation of phosphorylation
regulation of RNA splicing
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
nucleus organization
visual perception
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