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Invitrogen
B-cell lymphoma (Detumomab Biosimilar) Recombinant Mouse Monoclonal Antibody
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产品信息
MA562589
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
B-cell lymphoma is a type of non-Hodgkin lymphoma that develops in B lymphocytes, which are white blood cells responsible for producing antibodies. The genetic landscape of B-cell lymphomas is diverse, with key genetic aberrations identified in various subtypes. Chromosomal translocations, such as t(14;18) involving the BCL2 gene, are common in follicular lymphoma, leading to overexpression of the anti-apoptotic protein BCL2. In diffuse large B-cell lymphoma (DLBCL), mutations in genes such as MYC, BCL6, and TP53 are prevalent, contributing to aggressive disease behavior. Mantle cell lymphoma often involves the t(11;14) translocation, resulting in cyclin D1 overexpression, which drives cell cycle progression. Other genetic alterations in B-cell lymphomas include mutations in genes involved in the NF-kB pathway, NOTCH signaling, and epigenetic regulation, highlighting the complexity and heterogeneity of these malignancies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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