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Fabgennix
BACE2 A/C Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
BACE-201AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 56 kDa aspartic-like protease; AEPLC; ALP56; Asp1; ASP21; aspartyl protease 1; BACE2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP processing enzyme; beta-site APP-cleaving enzyme 2; CDA13; Down syndrome region aspartic protease; memapsin-1; membrane-associated aspartic protease 1; SLCO3A1/BACE2 fusion; theta-secretase; transmembrane aspartic proteinase Asp1; unnamed protein product; UNQ418/PRO852
基因别名: 1110059C24Rik; AEPLC; ALP56; ARP1; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
UniProt ID: (Human) Q9Y5Z0, (Mouse) Q9JL18, (Rat) Q6IE75
Entrez Gene ID: (Human) 25825, (Mouse) 56175, (Rat) 288227
proteolysis
membrane protein ectodomain proteolysis
protein processing
melanosome organization
glucose homeostasis
negative regulation of amyloid precursor protein biosynthetic process
beta-amyloid metabolic process
signaling receptor ligand precursor processing
astrocyte activation
peptide hormone processing
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