Proteintech

BARD1 Polyclonal Antibody

Name: BARD1 Polyclonal Antibody
Brand: Proteintech
SKU: 22964-1-AP

2 篇参考文献

查看其他8个BARD1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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BARD1 Antibody (22964-1-AP) in WB

SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 22964-1-AP ( BARD1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Immunogen image

Immunogen Image BARD1 Polyclonal Antibody

产品信息

22964-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:1,000

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

BARD1 Fusion Protein Ag18965 (428-777 aa encoded by BC126426)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.26 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: GETLLHIAS IKGDIPSVEY LLQNGSDPNV KDHAGWTPLH EACNHGHLKV VELLLQHKAL VNTTGYQNDS PLHDAAKNGH VDIVKLLLSY GASRNAVNIF GLRPVDYTDD ESMKSLLLLP EKNESSSASH CSVMNTGQRR DGPLVLIGSG LSSEQQKMLS ELAVILKAKK YTEFDSTVTH VVVPGDAVQS TLKCMLGILN GCWILKFEWV KACLRRKVCE QEEKYEIPEG PRRSRLNREQ LLPKLFDGCY FYLWGTFKHH PKDNLIKLVT AGGGQILSRK PKPDSDVTQT INTVAYHARP DSDQRFCTQY IIYEDLCNYH PERVRQGKVW KAPSSWFIDC VMSFELLPLD S (428-777 aa encoded by BC126426)

靶标信息

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。