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BCL10 Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
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Tech Support
BCL10 Polyclonal Antibody

Product Details

600-401-Z42

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

10 µg/mL
-

ELISA (ELISA)

1:10,000-1:20,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-Bcl10 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the N-terminus of human Bcl10.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; R-RCD1; RCD; RP11-234D19.2

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Gene Aliases: AI132454; BCL-10; BCL10; c-E10; C81403; CARMEN; cE10; CIPER; CLAP; IMD37; ME10

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UniProt ID: (Human) O95999, (Rat) Q9QYN5, (Mouse) Q9Z0H7

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Entrez Gene ID: (Human) 8915, (Rat) 83477, (Mouse) 12042

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Function(s)
protease binding transcription coactivator activity protein binding protein C-terminus binding transcription factor binding kinase activator activity enzyme binding kinase binding protein kinase binding ubiquitin protein ligase binding identical protein binding ubiquitin binding protein kinase B binding protein self-association NF-kappaB binding cysteine-type endopeptidase activator activity involved in apoptotic process protein homodimerization activity protein heterodimerization activity
Process(es)
B cell apoptotic process neural tube closure response to molecule of bacterial origin adaptive immune response negative regulation of mature B cell apoptotic process apoptotic process cellular defense response I-kappaB kinase/NF-kappaB signaling cell death response to fungus immunoglobulin mediated immune response positive regulation of protein ubiquitination response to food positive regulation of phosphorylation positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process fibroblast apoptotic process innate immune response positive regulation of interleukin-8 biosynthetic process positive regulation of transcription, DNA-templated T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity protein oligomerization protein homooligomerization protein heterooligomerization T cell apoptotic process thymocyte apoptotic process cellular response to mechanical stimulus positive regulation of extrinsic apoptotic signaling pathway stimulatory C-type lectin receptor signaling pathway toll-like receptor signaling pathway positive regulation of mast cell cytokine production Fc-epsilon receptor signaling pathway lymphotoxin A biosynthetic process interleukin-6 biosynthetic process immune system process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of JUN kinase activity regulation of apoptotic process mast cell activation positive regulation of execution phase of apoptosis
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