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Proteintech
BCL11A Polyclonal Antibody
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产品信息
11613-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BCL11A Fusion Protein Ag2187 (1-351 aa encoded by BC021098)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This is a rabbit polyclonal antibody raised against part chain of N-terminal BCL11A of human origin. There are three isoforms of BCL11A: isoform1 (773 aa), isoform2 (486 aa), and isoform3 (239 aa).
Immunogen sequence: MSRRKQGKP QHLSKREFSP EPLEAILTDD EPDHGPLGAP EGDHDLLTCG QCQMNFPLGD ILIFIEHKRK QCNGSLCLEK AVDKPPSPSP IEMKKASNPV EVGIQVTPED DDCLSTSSRG ICPKQEHIAD KLLHWRGLSS PRSAHGALIP TPGMSAEYAP QGICKDEPSS YTCTTCKQPF TSAWFLLQHA QNTHGLRIYL ESEHGSPLTP RVGIPSGLGA ECPSQPPLHG IHIADNNPFN LLRIPGSVSR EASGLAEGRF PPTPPLFSPP PRHHLDPHRI ERLGAEEMAL ATHHPSAFDR VLRLNPMAME PPAMDFSRRL RELAGNTSSP PLSPGRPSPM QRLLQPFQPG SK (1-351 aa encoded by BC021098)
靶标信息
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell lymphoma/leukemia 11A; BCL-11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; C2H2-type zinc finger protein; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; FLJ10173; FLJ34997; myeloid leukemia; Zinc finger protein 856
基因别名: 2810047E18Rik; BCL-11A; BCL11A; BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; CTIP1; D930021L15Rik; EVI9; Evi9a; Evi9b; Evi9c; HBFQTL5; KIAA1809; mKIAA1809; ZNF856
UniProt ID: (Human) Q9H165, (Mouse) Q9QYE3
Entrez Gene ID: (Human) 53335, (Rat) 305589, (Mouse) 14025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
metal ion binding
transcription corepressor activity
protein heterodimerization activity
nucleic acid binding
protein binding
DNA-binding transcription factor
zinc finger transcription factor
C2H2 zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
signal transduction
protein sumoylation
negative regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
B cell differentiation
T cell differentiation
negative regulation of collateral sprouting
positive regulation of collateral sprouting
regulation of dendrite development
negative regulation of nucleic acid-templated transcription
negative regulation of dendrite development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
