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Invitrogen
BCL11A Polyclonal Antibody
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BCL11A Antibody (PA5-114898) in IHC (P)
Immunohistochemistry analysis of BCL11A in rat brain tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114898) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-114898
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BCL11A(Accession Q9H165), corresponding to amino acid residues T180-I230.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total BCL11A.
靶标信息
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BCL-11A; BCL11 transcription factor A; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; FLJ10173; FLJ34997; myeloid leukemia; Zinc finger protein 856
基因别名: 2810047E18Rik; BCL-11A; BCL11A; CTIP1; D930021L15Rik; EVI9; Evi9a; Evi9b; Evi9c; KIAA1809; mKIAA1809; ZNF856
UniProt ID: (Mouse) Q9QYE3
Entrez Gene ID: (Rat) 305589, (Mouse) 14025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription corepressor activity
metal ion binding
protein heterodimerization activity
nucleic acid binding
protein binding
DNA-binding transcription factor
zinc finger transcription factor
C2H2 zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
negative regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
protein sumoylation
B cell differentiation
T cell differentiation
negative regulation of collateral sprouting
positive regulation of collateral sprouting
regulation of dendrite development
negative regulation of nucleic acid-templated transcription
negative regulation of dendrite development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
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