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Invitrogen
BCL2L12 Polyclonal Antibody
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产品信息
PA5-54267
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PSESPRPCSL PIRPCYGLEP GPATPDFYAL VAQRLEQLVQ EQLKSPPSPE LQGPPSTEKE AILRRLVALL EEEAEVINQK
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.
靶标信息
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Bcl-2 related proline-rich protein; Bcl-2-like protein 12; Bcl-2-related proline-rich protein; Bcl2-L-12; BCL2-like 12 (proline rich)
基因别名: BCL2L12; BPR
UniProt ID: (Human) Q9HB09
Entrez Gene ID: (Human) 83596
apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cellular senescence
