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Proteintech
BCL3 Polyclonal Antibody, CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
CL488-23959
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BCL3 fusion protein Ag21040
偶联物
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: NLPTPLYPM MCPMEHPLSA DIAMATRADE DGDTPLHIAV VQGNLPAVHR LVNLFQQGGR ELDIYNNLRQ TPLHLAVITT LPSVVRLLVT AGASPMALDR HGQTAAHLAC EHRSPTCLRA LLDSAAPGTL DLEARNYDGL TALHVAVNTE CQETVQLLLE RGADIDAVDI KSGRSPLIHA VENNSLSMVQ LLLQHGANVN AQMYSGSSAL HSASGRGLLP LVRTLVRSGA DSSLKNCHND TPLMVARSRR VIDILRGKAT RPASTSQPDP SPDRSANTSP ESSSRLSSNG LLSASPSSSP SQSPPRDPPG FPMAPPNFFL PSPSPPAFLP FAGVLRGPGR PVPPSPAPGG S
靶标信息
B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B cell CLL/lymphoma 3; B-cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; lymphoma 3-encoded protein (bcl-3); proto-oncogene BCL3; unnamed protein product
基因别名: Bcl-3; BCL4; D19S37
UniProt ID: (Human) P20749, (Mouse) Q9Z2F6
Entrez Gene ID: (Human) 602, (Mouse) 12051
negative regulation of cytokine production
follicular dendritic cell differentiation
marginal zone B cell differentiation
humoral immune response mediated by circulating immunoglobulin
germinal center formation
protein import into nucleus
response to stress
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
response to virus
response to UV-C
positive regulation of gene expression
antimicrobial humoral response
extracellular matrix organization
DNA damage response, signal transduction by p53 class mediator
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
T-helper 1 type immune response
defense response to bacterium
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
defense response to protozoan
regulation of apoptotic process
negative regulation of apoptotic process
T-helper 2 cell differentiation
positive regulation of translation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
spleen development
response to other organism
regulation of NIK/NF-kappaB signaling
negative regulation of NIK/NF-kappaB signaling
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
