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OriGene

BECN1 Monoclonal Antibody (OTI3H8), TrueMAB™

查看其他40个Beclin 1抗体

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BECN1 Monoclonal Antibody (OTI3H8), TrueMAB™

产品信息

CF502517

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:150
-

免疫细胞化学 (ICC/IF)

1:100
-

流式细胞分析 (Flow)

1:100
-
产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

OTI3H8

抗原

Full length human recombinant protein of human BECN1 produced in HEK293T cell.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 8% trehalose

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

靶标信息

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1-beta; beclin1-gamma; BECN; coiled-coil myosin-like BCL2-interacting protein; partial ORF; putative; testis secretory sperm-binding protein Li 215e; unnamed protein product

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基因别名: ATG6; Beclin1; VPS30

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UniProt ID: (Human) Q14457, (Rat) Q91XJ1

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Entrez Gene ID: (Human) 8678, (Rat) 114558

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功能
protein binding protein kinase binding protein binding, bridging ubiquitin protein ligase binding identical protein binding phosphatidylinositol 3-kinase binding GTPase binding binding, bridging
参与通路
autophagosome assembly mitophagy response to hypoxia cytoplasmic pattern recognition receptor signaling pathway autophagy cellular response to nitrogen starvation lysosome organization mitotic metaphase plate congression JNK cascade circadian rhythm negative regulation of cell proliferation protein secretion response to xenobiotic stimulus response to iron(II) ion response to lead ion regulation of autophagy negative regulation of autophagy positive regulation of autophagy positive regulation of cardiac muscle hypertrophy macroautophagy regulation of macroautophagy response to nutrient levels regulation of cytokinesis receptor catabolic process response to vitamin E cellular response to amino acid starvation phosphatidylinositol-3-phosphate biosynthetic process p38MAPK cascade cellular response to glucose starvation negative regulation of apoptotic process negative regulation of programmed cell death engulfment of apoptotic cell early endosome to late endosome transport late endosome to vacuole transport neuron development beta-amyloid metabolic process regulation of catalytic activity response to other organism bone development SMAD protein signal transduction positive regulation of stress granule assembly protein-containing complex assembly cellular response to hydrogen peroxide cellular response to aluminum ion cellular response to copper ion cellular response to epidermal growth factor stimulus cellular response to oxygen-glucose deprivation autophagosome maturation response to mitochondrial depolarisation positive regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of autophagosome assembly negative regulation of lysosome organization positive regulation of autophagosome assembly positive regulation of intrinsic apoptotic signaling pathway protein targeting to lysosome cellular defense response positive regulation of protein kinase B signaling
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