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BICD1 Polyclonal Antibody
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图: 1 / 3
BICD1 Antibody (600-401-Z62) in ICC/IF
Immunocytochemistry of BICD1 antibody. Tissue: Daudi cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: BICD1 antibody at 2.5 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: BICD1 is nuclear and occasionally cytoplasmic. Staining: BICD1 as precipitated brown signal with hematoxylin purple counterstain.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-401-Z62
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-BICD1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the C-terminus of human BICD1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bicaudal D homolog 1; cytoskeleton-like bicaudal D protein homolog 1; unnamed protein product
基因别名: B830009D06Rik; bic-D 1; BICD
UniProt ID: (Human) Q96G01, (Mouse) Q8BR07
Entrez Gene ID: (Human) 636, (Rat) 362466, (Mouse) 12121
virion assembly
protein localization to organelle
stress granule assembly
positive regulation of receptor-mediated endocytosis
regulation of microtubule cytoskeleton organization
minus-end-directed organelle transport along microtubule
microtubule anchoring at microtubule organizing center
negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of protein localization to centrosome
RNA processing
intracellular mRNA localization
anatomical structure morphogenesis
constitutive secretory pathway
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