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BMPR1A (extracellular) Polyclonal Antibody

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BMPR1A (extracellular) Polyclonal Antibody

产品信息

ABR-043-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化（冰冻） (IHC (F))

1:300
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-

流式细胞分析 (Flow)

5 µg
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide APVHRDWRVHLALD, corresponding to amino acid residues 291-304 of mouse GPR142. Extracellular, 3rd loop.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunogen sequence: APVHRDWRVHLALD

Reconstitution: 50 uL double distilled water (DDW). The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; Bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5

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基因别名: 10q23del; 1110037I22Rik; ACVRLK3; ALK3; AU045487; Bmpr; BMPR-IA; BMPR1A; CD292; SKR5

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UniProt ID: (Human) P36894, (Rat) Q78EA7, (Mouse) P36895

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Entrez Gene ID: (Human) 657, (Rat) 81507, (Mouse) 12166

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功能
RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity molecular_function transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
参与通路
in utero embryonic development mesoderm formation somitogenesis Mullerian duct regression positive regulation of mesenchymal cell proliferation chondrocyte differentiation outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis endocardial cushion formation protein phosphorylation immune response transforming growth factor beta receptor signaling pathway ectoderm development dorsal/ventral axis specification regulation of cardiac muscle cell apoptotic process positive regulation of pathway-restricted SMAD protein phosphorylation neural crest cell development negative regulation of smooth muscle cell migration stem cell population maintenance pituitary gland development neural plate mediolateral regionalization signal transduction by protein phosphorylation lung development positive regulation of bone mineralization BMP signaling pathway hindlimb morphogenesis dorsal aorta morphogenesis odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm structural organization lateral mesoderm development regulation of lateral mesodermal cell fate specification mesendoderm development embryonic organ development developmental growth positive regulation of epithelial cell proliferation negative regulation of neurogenesis palate development regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of SMAD protein import into nucleus heart formation pharyngeal arch artery morphogenesis cellular response to BMP stimulus positive regulation of cardiac ventricle development positive regulation of vascular smooth muscle cell proliferation regulation of cellular senescence regulation of endothelial cell proliferation heart morphogenesis transcription from RNA polymerase II promoter pattern specification process nervous system development endoderm development heart development biological_process anterior/posterior pattern specification dorsal/ventral pattern formation cell differentiation regulation of endothelial cell differentiation positive regulation of transcription, DNA-templated paraxial mesoderm development embryonic morphogenesis cartilage development neural plate pattern specification transmembrane receptor protein serine/threonine kinase signaling pathway phosphorylation
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